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Pharmacological editor During sexual stimulation, the parasympathetic nerves, non-adrenergic non-cholinergic nerve (NANC) endings and vascular endothelial cells release nitricoxide (NO) under the action of nitricoxide synthase (NOS). In the blood vessels, It is usually activated by NO to soluble guanlykcyckase (SGC), which acts on guanosine triphosphate to produce cGMP. CGMP in the cavernous body can induce erection by reducing the concentration of Ca2+ in the cavernous vascular smooth m... -
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It is a kind of PDE-5 inhibitors which can be used for the treatment of male erectile dysfunction. It is also the second generation of phosphodiesterase type 5 inhibitors used to treat male erectile dysfunction.
